mRNA pipeline

Research

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Our mRNA pipeline shows the progress we’re making on clinical programs currently in development to create mRNA medicines for a wide range of diseases and conditions.

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Program Indication

ID #

Preclinical Development

Phase 1

Phase 2

Phase 3

Commercial

Moderna rights

Respiratory Vaccines

Adults

COVID-19 vaccine

mRNA-1273/Spikevax®

Commercial

Moderna rights : Worldwide

COVID-19 vaccine Omicron variant + wild-type

mRNA-1273.214

Commercial

Moderna rights : Worldwide

COVID-19 vaccine Omicron (BA.4/5) variant + wild-type

mRNA-1273.222

Commercial

Moderna rights : Worldwide

COVID-19 vaccine Omicron variant

mRNA-1273.529

Phase 3

Moderna rights : Worldwide

COVID-19 vaccine Beta variant

mRNA-1273.351

Phase 2

Moderna rights : Worldwide

COVID-19 vaccine Delta variant

mRNA-1273.617

Phase 2

Moderna rights : Worldwide

COVID-19 vaccine Beta variant + wild-type

mRNA-1273.211

Phase 2

Moderna rights : Worldwide

COVID-19 vaccine Beta + Delta variant

mRNA-1273.213

Phase 2

Moderna rights : Worldwide

COVID-19 vaccine Next generation (2-5 ºC)

mRNA-1283

Phase 2

Moderna rights : Worldwide

Flu vaccine

mRNA-1010

Phase 3

Moderna rights : Worldwide

Flu vaccine

mRNA-1020

Phase 1

Moderna rights : Worldwide

Flu vaccine

mRNA-1030

Phase 1

Moderna rights : Worldwide

Flu vaccine

mRNA-1011

Preclinical Development

Moderna rights : Worldwide

Flu vaccine

mRNA-1012

Preclinical Development

Moderna rights : Worldwide

Older adults respiratory syncytial virus (RSV) vaccine

mRNA-1345

Phase 3

Moderna rights : Worldwide

COVID + Flu vaccine mRNA-1273 mRNA-1010

mRNA-1073

Phase 1

Moderna rights : Worldwide

COVID + Flu + RSV vaccine

mRNA-1230

Phase 1

Moderna rights : Worldwide

Endemic HCoV vaccine

mRNA-1287

Preclinical Development

Moderna rights : Worldwide

Flu + RSV vaccine

mRNA-1045

Phase 1

Moderna rights : Worldwide

Adolescents and Pediatrics

COVID-19 (adolescents) TeenCOVE

mRNA-1273

Commercial

Moderna rights : Worldwide

COVID-19 vaccine (pediatrics) KidCOVE

mRNA-1273

Commercial

Moderna rights : Worldwide

Pediatric RSV vaccine

mRNA-1345

Phase 1

Moderna rights : Worldwide

Pediatric hMPV+PIV3 vaccine

mRNA-1653

Phase 1

Moderna rights : Worldwide

Pediatric RSV + hMPV vaccine

mRNA-1365

Preclinical Development

Moderna rights : Worldwide

Latent & Public Health Vaccines

Latent Vaccines

CMV vaccine

mRNA-1647

Phase 3

Moderna rights : Worldwide

EBV vaccine (to prevent infectious mononucleosis)

mRNA-1189

Phase 1

Moderna rights : Worldwide

EBV vaccine (to prevent long term EBV sequelae)

mRNA-1195

Preclinical Development

Moderna rights : Worldwide

HSV Vaccine

mRNA-1608

Preclinical Development

Moderna rights : Worldwide

VZV Vaccine

mRNA-1468

Preclinical Development

Moderna rights : Worldwide

HIV vaccine

mRNA-1644

Phase 1

Moderna rights : Worldwide IAVI/others funded

HIV vaccine

mRNA-1574

Phase 1

Moderna rights : Worldwide IAVI/BMGF/NIAID and others funded

Public Health Vaccines

Zika vaccine

mRNA-1893

Phase 2

Moderna rights : Worldwide BARDA funded

Nipah vaccine

mRNA-1215

Phase 1

Moderna rights : Worldwide NIH funded

Therapeutics

Systemic Secreted & Cell Surface Therapeutics

Relaxin

mRNA-0184

Phase 1

Moderna rights : Worldwide

PD-L1 Autoimmune hepatitis

mRNA-6981

Preclinical Development

Moderna rights : Worldwide

Cancer Vaccines

Personalized cancer vaccine (PCV)

mRNA-4157

Phase 2

Moderna rights : 50-50 global profit sharing with Merck

KRAS vaccine

mRNA-5671

Phase 1

Moderna rights : Worldwide

Checkpoint Vaccine

mRNA-4359

Phase 1

Moderna rights : Worldwide

Intratumoral Immuno-Oncology

OX40L/IL-23/IL-36γ (Triplet) Solid tumors/lymphoma

mRNA-2752

Phase 1

Moderna rights : Worldwide

IL-12 Solid tumors

MEDI1191

Phase 1

Moderna rights : Worldwide

Localized Regenerative Therapeutics

VEGF-A Myocardial ischemia

AZD8601

Phase 2

Moderna rights : Worldwide

Systemic Intracellular Therapeutics

PCCA/PCCB Propionic acidemia (PA)

mRNA-3927

Phase 2

Moderna rights : Worldwide

MUT Methylmalonic acidemia (MMA)

mRNA-3705

Phase 1

Moderna rights : Worldwide

G6Pase Glycogen Storage Disease Type 1a (GSD1a) Open IND

mRNA-3745

Phase 1

Moderna rights : Worldwide

Ornithine transcarbamylase deficiency (OTC)

mRNA-3139

Preclinical Development

Moderna rights : Worldwide

PAH Phenylketonuria (PKU)

mRNA-3283

Preclinical Development

Moderna rights : Worldwide

Crigler-Najjar Syndrome Type 1 (CN-1)

mRNA-3351

Preclinical Development

Moderna rights : Provided by ILCM, Institute for Life Changing Medicines free of charge

Inhaled Pulmonary Therapeutics

Cystic Fibrosis (CF)

VX-522

Phase 1

Moderna rights : Vertex to pay milestones and royalties

Abbreviations :

AZ : AstraZeneca

CMV : cytomegalovirus

CRC : colorectal cancer

G6Pase : glucose 6-phosphatase

hMPV : human metapneumovirus

IL12 : interleukin 12

IL23 : interleukin 23

IL36γ : interleukin 36 gamma

MUT : methylmalonyl-CoA mutase

NSCLC : non-small cell lung cancer

PAH : phenylalanine hydroxylase

PCCA/PCCB : propionyl-CoA carboxylase subunit A/B

PCV : personalized cancer vaccine

PIV3 : human parainfluenza 3

RSV : respiratory syncytial virus

VEGF-A : vascular endothelial growth factor A